Drug Discovery Research Screening Libraries
Apexbio Technology LLC DiscoveryProbe™ Stem Cell Compound Library Plus, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
DiscoveryProbe™ Stem Cell Compound Library Plus is a unique collection of 280 stem cell-related compounds for stem cell research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
AdipoGen Selumetinib
Chemical. CAS 606143-52-6. Formula C17H15BrClFN4O3. MW 457.7. Selumetinib is an orally available, potent and selective ATP non-competitive inhibitor of the mitogen-activated protein kinases MEK1 IC50 = 14 nM and MEK2 Kd = 530 nM. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. It inhibits ERK1/2 phosphorylation IC50 = 10 nM, but exhibits only weak activity at p38α, MKK6, EGFR, ErbB2 and ERK2. Selumetinib inhibits growth of several tumor cell lines but not normal fibroblast lines and shows potent dose-dependent antitumor activity against a panel of mouse xenograft models of colorectal, pancreatic, liver, skin and lung cancer.
AdipoGen Rutin trihydrate
Chemical. CAS 250249-75-3. Formula C27H30O16 . 3H2O. MW 664.5. Synthetic. A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase beta and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
AdipoGen Vaspin h rec MultiPack
Protein. Human vaspin aa 21-414 is fused at the N-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Vaspin Visceral adipose tissue-derived serpin Serpin A12, a serine protease inhibitor serpin, is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome.
AdipoGen NMNAT1 hHishighly active
Protein. Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM sodium phosphate, pH8.0, containing 300mM sodium chloride, 2mM DTT and 10% glycerol. Purity >95% SDS-PAGE. Nuclear NMNAT isoform. Catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. It can also use the deamidated form of nicotinic acid mononucleotide NAMN as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.
AdipoGen Rubpy2phen-5-NH2PF62
Chemical. CAS 84537-86-0. Formula C32H25N7Ru . 2PF6. MW 898.59. Rubpy2phen-5-NH2PF62 is a fluorescent metal-ligand complex probe. It shows high brightness and large Stokes Shift. Spectral Data lambdaex=458nm lambdaem=612nm in 0.1 M Tris pH 7.0. It has been used as starting material for synthesis of long-lifetime luminescent Ru complexes and in the preparation of amino-rutheniumii complex functionalized gold nanoparticles, which could be used as probe in biosensors and bioassays. Rubpy2phen-5-NH2PF62 is has also been used to synthesize fluorescent silica nanoparticles with ultrabrightness and photostability by encapsulating it into silica nanoparticles by a modified reversed microemulsion method. Could be used for the determination of nucleotide base sequences.
Apexbio Technology LLC DiscoveryProbe™ Anti-diabetic Compound Library, 100uL/well(10 mM solution),96 Well Racks With Screw Cap
A unique collection of 110 anti-diabetic small molecule compounds for diabetes research. Other sizes are available. Please inqury us for quote.
Abcam GANT58, Hh signaling inhibitor, 10MG
MW 392.48 g/mol, Purity >99%. Inhibits Hh signaling downstream of smo and sufu. IC₅₀ = 5 μM for glioma associated oncogene expression in MEFs.
The product is subject to the following: Abcam Restricted Use Statement
Cytek Biosciences Inc Autophagy LC3 Detection Am
Product Name: Guava Autophagy LC3 Antibody-Based Detection Kit
Cytek Catalog Number: FCCH100171
Product Class: Guava Muse Reagent
Type: easyCyte
Size: 100 Tests
AdipoGen A-674563 free base
Chemical. CAS 552325-73-2. Formula C22H22N4O. MW 358.4. Synthetic. A-674563 is a potent, ATP-competitive, reversible and orally available Akt1 inhibitor with an IC50 of 11nM. Binds to the ATP site of the AKT kinase domain, inhibiting AKT-catalyzed phosphorylation activity. Also inhibits PKA and CDK2 with IC50 values of 16nM and 46nM, respectively. 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK and TK families. Anticancer compound. Reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4µM. Shown to decrease tumor growth in mouse tumor xenograft models. Decreased sphingosine kinase 1 SphK1 activity in AML cells to deplete pro-survival sphingosine-1-phosphate S1P and boost pro-apoptotic ceramide production.
Enzo Life Sciences SCREEN-WELL Serotonergic ligand library (500 µl/well)
The Serotonergic Ligands Plate contains 79 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Serotonergic Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 680 ligands. Long Term Storage: -80°C. Applications: HTS .
Apexbio Technology LLC DiscoveryProbe™ Immunology/Inflammation Compound Library Plus, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
DiscoveryProbe™ Immunology/Inflammation Compound Library Plus is a unique collection of 806 small molecule compounds for immunology/inflammation research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
AdipoGen Mubritinib
Chemical. CAS 366017-09-6. Formula C25H23F3N4O2. MW 468.5. Mubritinib TAK-165 is a selective inhibitor of the human epidermal growth factor receptor 2 EGFR2 HER2, inhibiting HER2 phosphorylation with an IC50 value of 6nM. It is 4000-fold selective over EGFR, FGFR, PDGFR, JAK1, Src and Blk IC50 > 25μM. Mubritinib inhibits the proliferation of breast, bladder, kidney and prostate cancer cells in vitro and in vivo. Mubritinib was shown to inhibit autophagy in a HER2-independent manner in cancer cells. Recently shown to be a mitochondrial electron transport chain complex I NADH-CoQ reductase inhibitor. Mubritinib functions through ubiquinone-dependent inhibition of electron transport chain ETC complex I activity and consequently oxidative phosphorylation OXPHOS. This agent could be useful for immunometabolism research. Inhibition of electron transport chain in mitochondria leads to blocking of the transfer of electrons from iron-sulfur centers in complex I to ubiquinone.
Apexbio Technology LLC DiscoveryProbe™ Neuronal Signaling Compound Library Plus, 100uL/well(10 mM solution),96 Well Racks With Screw Cap
DiscoveryProbe™ Neuronal Signaling Compound Library Plus is a unique collection of 948 neuronal signaling-related small molecules for neuroscience reasearch. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ JAK/STAT Compound Library, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 109 JAK/STAT inhibitors for JAK/STAT signaling pathway research. Other sizes are available. Please inqury us for quote.